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副研究员

姓名 蒋书恒 性别
专家类别 上海市晨光计划
学历 博士 职称 副研究员
联系电话 电子邮箱 shjiang@shsci.org
通讯地址 上海市闵行区东川路800号文选医学大楼419室
个人简介

教育经历

(1) 2015-9至2018-6, 复旦大学, 病原生物学, 博士

(2) 2012-9至2015-6, 复旦大学, 病原生物学, 硕士

(3) 2007-9至2012-6, 华北煤炭医学院, 临床医学, 学士

工作经历:

(1) 2021-1至现在, 上海交通大学, 医学院附属仁济医院彩神app注册邀请码, 副研究员

(2) 2018-8至2020-12, 上海交通大学, 医学院附属仁济医院彩神app注册邀请码, 助理研究员

 

作为负责人主持国家自然科学基金青年项目1 项,获得上海市“扬帆计划”和“晨光计划”人才项目资助。相关研究成果以第一和通讯作者(含共同)在 Gastroenterology、Gut、Nature Communications、Clinical Cancer Research、Molecular Cancer、Oncogene和Theranostics等期刊发表。担任中国抗癌协会肿瘤微环境专业委员会青年委员。获复旦大学第八届学术之星、2018年上海市优秀毕业生、第三届全国胰腺肿瘤大会投稿论文一等奖和第十七届上海市医学科技奖二等奖等荣誉称号。


研究方向

1. 肿瘤的神经调控

2. 胰腺癌发生发展分子机制研究


科研论文

1. Xu Wang#; Li-Peng Hu#; Wei-Ting Qin#; Qin Yang#; De-Yu Chen#; Qing Li; Kai-Xia Zhou; Pei-Qi Huang; Chun-Jie Xu; Jun Li; Lin-Li Yao; Ya-Hui Wang; Guang-Ang Tian; Jian-Yu Yang; Min-Wei Yang; De-Jun Liu; Yong-Wei Sun*; Shu-Heng Jiang*; Xue-Li Zhang*; Zhi-Gang Zhang*; Identification of a subset of immunosuppressive P2RX1-negative neutrophils in pancreatic cancer liver metastasis, Nature Communications, 2021, 12(1): 174.

2. Jiang, Shu-Heng#; Zhang, Xiao-Xin#; Hu, Li-Peng; Wang, Xu; Li, Qing; Zhang, Xue-Li; Li, Jun; Gu, Jian-Ren*; Zhang, Zhi-Gang*; Systemic Regulation of Cancer Development by Neuro-Endocrine-Immune Signaling Network at Multiple Levels , Frontiers in Cell and Developmental Biology, 2020, 8: 586757.

3. Jiang, Shu-Heng#; Dong, Fang-Yuan#; Da, Lin-Tai; Yang, Xiao-Mei; Wang, Xiao-Xue; Weng, Jing-Yi; Feng, Lei; Zhu, Li-Li; Zhang, Yan-Li; Zhang, Zhi-Gang; Sun, Yong-Wei; Li, Jun*; Xu, Min-Juan*; Ikarugamycin inhibits pancreatic cancer cell glycolysis by targeting hexokinase 2 , The FASEB Journal, 2020, 34(3): 3943-3955.

4. Jiang, Shu-Heng#; Hu, Li-Peng#; Wang, Xu; Li, Jun; Zhang, Zhi-Gang*; Neurotransmitters: emerging targets in cancer , Oncogene, 2020, 39(3): 503-515.

5. Zhang, Junfeng#; Yang, Jianyu#; Lin, Chaoyi#; Liu, Wei; Huo, Yanmiao; Yang, Minwei; Jiang, Shu-Heng*; Sun, Yongwei*; Hua, Rong*; Endoplasmic Reticulum stress-dependent expression of ERO1L promotes aerobic glycolysis in Pancreatic Cancer , Theranostics, 2020, 10(18): 8400-8414.

6. Jiang, Shu-Heng#; Zhu, Li-Li#; Zhang, Man#; Li, Rong-Kun#; Yang, Qin#; Yan, Jiang-Yu; Zhang, Ce; Yang, Jian-Yu; Dong, Fang-Yuan; Dai, Miao; Hu, Li-Peng; Li, Jun; Li, Qing; Wang, Ya-Hui; Yang, Xiao-Mei; Zhang, Yan-Li; Nie, Hui-Zhen; Zhu, Lei; Zhang, Xue-Li; Tian, Guang-Ang; Zhang, Xiao-Xin; Cao, Xiao-Yan; Tao, Ling-Ye; Huang, Shan; Jiang, Yong-Sheng; Hua, Rong; Luo, Kathy Qian; Gu, Jian-Ren; Sun, Yong-Wei*; Hou, Shangwei*; Zhang, Zhi-Gang*; GABRP regulates chemokine signalling, macrophage recruitment and tumour progression in pancreatic cancer through tuning KCNN4-mediated Ca2+ signalling in a GABA-independent manner , Gut, 2019, 68(11): 1994-2006.

7. Li, Rongkun#; Wang, Yahui#; Zhang, Xiaoxin; Feng, Mingxuan; Ma, Jun; Li, Jun; Yang, Xiaomei; Fang, Fang; Xia, Qiang; Zhang, Zhigang*; Shang, Mingyi*; Jiang, Shuheng*; Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis , Molecular Cancer, 2019, 18: 18.

8. Hu, Li-Peng#; Zhang, Xiao-Xin#; Jiang, Shu-Heng#; Tao, Ling-Ye; Li, Qing; Zhu, Li-Li; Yang, Ming-Wei; Huo, Yan-Miao; Jiang, Yong-Sheng; Tian, Guang-Ang; Cao, Xiao-Yan; Zhang, Yan-Li; Yang, Qin; Yang, Xiao-Mei; Wang, Ya-Hui; Li, Jun; Xiao, Gary Guishan*; Sun, Yong-Wei*; Zhang, Zhi-Gang*; Targeting Purinergic Receptor P2Y2 Prevents the Growth of Pancreatic Ductal Adenocarcinoma by Inhibiting Cancer Cell Glycolysis , Clinical Cancer Research, 2019, 25(4): 1318-1330.

9. Li, Jun#; Wang, Yahui#; Ma, Mingze#; Jiang, Shuheng#; Zhang, Xueli; Zhang, Yanli; Yang, Xiaomei; Xu, Chunjie; Tian, Guangang; Li, Qing; Wang, Yang; Zhu, Lei; Nie, Huizhen; Feng, Mingxuan; Xia, Qiang; Gu, Jianren; Xu, Qing*; Zhang, Zhigang*; Autocrine CTHRC1 activates hepatic stellate cells and promotes liver fibrosis by activating TGF-beta signaling , EBioMedicine, 2019, 40: 43-55.

10. Dong, Fangyuan#; Jiang, Shuheng#; Li, Jun; Wang, Yahui; Zhu, Lili; Huang, Yiqin; Jiang, Xin; Hu, Xiaona*; Zhou, Qi*; Zhang, Zhigang*; Bao, Zhijun*;The histone demethylase KDM4D promotes hepatic fibrogenesis by modulating Toll-like receptor 4 signaling pathway , EBioMedicine, 2019, 39: 472-483.

11. Jiang, Shu-Heng#; Li, Jun#; Dong, Fang-Yuan#; Yang, Jian-Yu; Liu, De-Jun; Yang, Xiao-Mei; Wang, Ya-Hui; Yang, Min-Wei; Fu, Xue-Liang; Zhang, Xiao-Xin; Li, Qing; Pang, Xiu-Feng; Huo, Yan-Miao; Li, Jiao; Zhang, Jun-Feng; Lee, Ho-Young; Lee, Su-Jae; Qin, Wen-Xin; Gu, Jian-Ren; Sun, Yong-Wei*; Zhang, Zhi-Gang*; Increased Serotonin Signaling Contributes to the Warburg Effect in Pancreatic Tumor Cells Under Metabolic Stress and Promotes Growth of Pancreatic Tumors in Mice, Gastroenterology, 2017, 153(1): 277-291.


科研项目

1. 国家自然科学基金委员会,青年科学基金项目,81902370,转录因子ONECUT3调控胰腺癌Warburg效应促进免疫抑制微环境的形成及其机制研究,2020-01至2022-12,在研,主持

2. 上海市科学技术委员会,扬帆计划,19YF1445700,GABRP调控肿瘤相关巨噬细胞促进胰腺癌生长和转移的机制研究,2019-05至2022-04,在研,主持

3. 上海市教育委员会,晨光计划,19CG17,GABRP在胰腺癌恶性转化过程的作用与机制研究,2020-05至2022-04,在研,主持


获得专利

徐岷涓、张志刚、徐俊、杨小妹、何昆燕、余河霖、蒋书恒. 多环稠合大环内酰胺类化合物的抗胰腺癌用途. 2019.1,中国,ZL201610372876.8


实验室成员
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