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研究员

姓名 洪洁 性别
专家类别 上海市优秀青年学科带头人
学历 博士 职称 研究员
联系电话 1385691936 电子邮箱 jiehong97@sjtu.edu.cn
通讯地址 上海市徐汇区斜土路2200弄25号彩神app注册邀请码
个人简介

现任癌基因及相关基因国家重点实验室,肿瘤表观遗传和计算生物信息学研究组组长,研究员,上海交通大学医学院博士生导师。美国肿瘤研究协会(AACR)会员,上海市消化病学会肿瘤学组委员。

目前的研究方向是消化道疾病发生发展的分子机制,具体围绕胃肠道表观遗传修饰、肠道菌群紊乱和信号通路展开研究。近5年以第一作者或共同通讯作者先后在Cell、Cancer Discovery、Gut、Nature Communications、Clin Cancer Res和Molecular Cancer等著名期刊发表SCI论著20篇(影响因子超过160分,单篇最高31.4分,5分以上SCI论著16篇)。

作为项目负责人获国家自然科学基金多项项目资助。入选教育部及省部级多项人才计划;以第三完成人获2018年国家科技进步二等奖。


研究方向

1.       肠道菌群紊乱与肿瘤和相关代谢性疾病发生发展及其免疫调控的机制研究

2.       RNA m6A甲基化修饰、lncRNA、microRNA及circular RNA等非编码RNA在肿瘤发生发展中的作用研究

3.       外泌体中lncRNA、microRNA及circular RNA等非编码RNA作为非侵入性疾病发生发展及预后判定的诊断标志物发现


科研论文

(1). Risk SNP-induced lncRNA-SLCC1 drives colorectal cancer through activating glycolysis signaling. Yan T#, Shen C#, Jiang P#, Yu C, Guo F, Tian X, Zhu X, Lu S, Han B, Zhong M, Chen J, Liu Q, Chen Y, Zhang J*, Hong J*, Chen H*, Fang JY*. Signal Transduct Target Ther. 2021;6(1):70. (共同通讯作者,IF=13.5)

 

(2). A tumor microenvironment-specific gene expression signature predicts chemotherapy resistance in colorectal cancer patients. Zhu X#, Tian X#, Ji L#, Zhang X, Cao Y, Shen C, Hu Y, Wong JWH, Fang JY*, Hong J*, Chen H*. NPJ Precis Oncol. 2021;5(1):7. doi: 10.1038/s41698-021-00142-x(共同通讯作者,2019 IF=7.7)

 

(4). F. nucleatum targets lncRNA ENO1-IT1 to promote glycolysis and oncogenesis in colorectal cancer. Hong J#*, Guo F#, Lu SY#, Shen C, Ma D, Zhang X, Xie Y, Yan T, Yu T, Sun T, Qian Y, Zhong M, Chen J, Peng Y, Wang C, Zhou X, Liu J, Liu Q, Ma X, Chen YX, Chen H*, Fang JY*.Gut. 2020 Dec 14:gutjnl-2020-322780. (#共同第一作者,*共同通讯作者 2019 IF=19.8)

 

(5)Single cell transcriptome revealed SARS-CoV-2 entry genes enriched in colon tissues and associated with coronavirus infection and cytokine production. Chen H#, Zou TH#, Xuan B, Yan Y, Yan T, Shen C, Zhao G, Chen YX, Xiao X, Hong J*, Fang JY*. Signal Transduct Target Ther. 2020 Jul 8;5(1):121. doi: 10.1038/s41392-020-00237-0. (*共同通讯作者 2019 IF=13.5)

 

(6) m6A-dependent glycolysis enhances colorectal cancer progression. Shen C#, Xuan B#, Yan T#, Ma Y, Xu P, Tian X, Zhang X, Cao Y, Ma D, Zhu X, Zhang Y, Fang JY*, Chen H*, Hong J*. Mol Cancer. 2020 Apr 3;19(1):72. (*共同通讯作者 2019 IF=15.3)

 

(7) LncRNA GLCC1 promotes colorectal carcinogenesis and glucose metabolism by stabilizing c-Myc. Tang J#, Yan T#, Bao Y#, Shen C, Yu C, Zhu X, Tian X, Guo F, Liang Q, Liu Q, Zhong M, Chen J, Ge Z, Li X, Chen X, Cui Y, Chen Y, Zou W, Chen H*, Hong J*, Fang JY*. Nat Commun. 2019 Aug 2;10(1):3499. (*共同通讯作者 2019 IF=12.1)

 

(8) Yu T#, Guo F#, Yu Y, Sun T, Ma D, Han J, Qian Y, Kryczek I, Sun D, Nagarsheth N, Chen Y*, Chen H*, Hong J*, Zou W*, Fang JY*. Fusobacterium nucleatum Promotes Chemoresistance to Colorectal Cancer by Modulating Autophagy. Cell 2017; 170(3):548-563.e16(*共同通讯作者 2019 IF=38.6)

 

(9) Yu CY#, Han JX#, Zhang J#, Jiang P, Shen C, Guo F, Tang J, Yan T, Tian X, Zhu X, Ma D, Hu Y, Xie Y, Du W, Zhong M, Chen J, Liu Q, Sun D, Chen Y, Zou W, Hong J*, Chen H*, Fang JY*. A 16q22.1 variant confers susceptibility to colorectal cancer as a distal regulator of ZFP90. Oncogene. 2019 Oct 22. doi: 10.1038/s41388-019-1055-4(*共同通讯,2019 IF=7.9)

 

(10) Sun TT#, He J#, Liang Q, Ren LL, Yan TT, Yu TC, Tang JY, Bao YJ, Hu Y, Lin Y, Sun D, Chen YX, Hong J*, Chen H*, Zou W*, Fang JY*. LncRNA GClnc1 Promotes Gastric Carcinogenesis and May Act as a Modular Scaffold of WDR5 and KAT2A Complexes to Specify the Histone Modification Pattern. Cancer Discov 2016; 6(7):784-801.(*共同通讯作者 2019 IF=29.5)

 

(11)Liang Q#, Ma D#, Zhu X#, Wang Z#, Sun TT#, Shen C, Yan T, Tian X, Yu T, Guo F, Tang J, Lin Y, Chen H, Zhou C, Ge Z, Zhong M, Chen J, Liu Q, Wang Z, Fang JY*, Chen HY*, Hong J*. RING-finger protein 6 amplification activates JAK/STAT3 pathway by modifying SHP-1 ubiquitylation and associates with poor outcome in colorectal cancer. Clin Cancer Res. 2018; 24(6):1473-1485.(*共同通讯作者 2019 IF=10.1)

 

(12) Yan TT#, Ren LL#, Shen CQ, Wang ZH, Yu YN, Liang Q, Tang JY, Chen YX, Sun DF, Zgodziński W, Majewski M, Radwan P, Kryczek I, Zhong M, Chen J, Liu Q, Zou W*, Chen HY*, Hong J*, Fang JY*. MicroRNA-508 defines the stem-like/mesenchymal subtype in colorectal cancer. Cancer Res 2018; 78(7):1751-1765.(*共同通讯作者 2019 IF=9.73)

 

(13) Ma D#, Cao Y#, Wang Z#, He J#, Chen H#, Xiong H#, Ren L#, Shen C, Zhang X, Yan Y, Yan T, Guo F, Xuan B, Cui Z, Ye G, Fang JY*, Chen H*, Hong J*. CCAT1 lncRNA Promotes Inflammatory Bowel Disease Malignancy by Destroying Intestinal Barrier via Downregulating miR-185-3p. Inflamm Bowel Dis. 2019.5, 25(5):862-874. (*通讯作者 2019 IF=4.3)

 

(14) Shen C#, Yan T#, Wang Z#, Su HC#, Zhu X, Tian X, Fang JY*, Chen H*, Hong J*. Variant of SNP rs1317082 at CCSlnc362 (RP11-362K14.5) creates a binding site for miR-4658 and diminishes the susceptibility to CRC. Cell Death Dis. 2018; 9(12):1177. (*通讯作者 2019 IF=6.3)

 

(15) Zhu X#, Tian X#, Sun T#, Yu C, Cao Y, Yan T, Shen C, Lin Y, Fang JY*, Hong J*, Chen H*. GeneExpressScore Signature: A robust prognostic and predictive classifier in gastric cancer. Mol Oncol 2018; 12(11):1871-1883.(*共同通讯作者 2019 IF=6.6)

 

(16) Ren LL#, Yan TT#, Shen CQ#, Tang JY, Kong X, Wang YC, Chen J, Liu Q, He J, Zhong M, Chen HY*, Hong J*, Fang JY*. The distinct role of strand-specific miR-514b-3p and miR-514b-5p in colorectal cancer metastasis. Cell Death Dis 2018; 9(6):687.(*共同通讯作者 2019 IF=6.3)

 

(17) Tian X#, Zhu X#, Yan T, Yu C, Shen C, Hu Y,  Hong J*, Chen H*, Fang JY*. Recurrence-associated gene signature optimizes recurrence-free survival prediction of colorectal cancer. Mol Oncol 2017; 11(11):1544-1560.(*共同通讯作者 2019 IF=6.6)

 

(18) Zhu X#, Tian X#, Yu C#, Shen C#, Yan T#, Hong J*, Wang Z*, Fang JY*, Chen H*. A long non-coding RNA signature to improve prognosis prediction of gastric cancer. Mol Cancer 2016; 15(1):60.(*共同通讯作者 2019 IF=15.3)


科研项目

(1)国家自然科学基金面上项目, 2019/01-2022/12

(2)上海市曙光计划, 2017/09-2020/09

(3)上海市优秀青年学科带头人, 2019/5-2022/5


获得专利
实验室成员

陈豪燕、宣宝琴、曹颖颖、张昕雨、严宇青、马燕如、胡慕妮


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