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研究员

姓名 段友容 性别
专家类别 中国抗癌协会纳米肿瘤学专业委员会委员、中美纳米医学暨纳米生物技术学会(CASNN)会员、中国微米纳米技术学会高级会员、中国医药生物技术协会纳米生物技术分会委员
学历 博士 职称 研究员
联系电话 021-64437139 电子邮箱 yrduan@@shsci.org
通讯地址 上海市徐汇区斜土路2200弄25号
个人简介

2002年6月毕业于四川大学,获生物医学工程学博士学位,随后进入华西医科大学药学院进行博士后研究。2005年进入彩神app注册邀请码癌基因及相关基因国家重点实验室工作。具有多学科交叉研究背景,长期从事药物载体及纳米缓控释给药系统的研究,在纳米药物载体的设计和制备方面具有丰富的经验和相关知识的积累。作为课题负责人先后在材料学、药学和医学领域承担国家自然科学基金面上项目6项,作为课题副组长参加国家自然科学基金重点项目1项,作为主研人员参加国家973项目和863项目的研究工作。获得四川省科技进步一等奖和三等奖各一项。在Advanced Functional Materials; ACS Nano; Biomaterials; Nanotoxicology; J. Biomed. Nanotech.; ACS Appl. Mater. & Inter.等国际主流期刊上发表论文100余篇。申请中国发明专利20项,获得授权发明专利12项(已获转让2项)。


研究方向

1.逆转或降低肿瘤耐药性药物递送系统设计及应用;

2.肿瘤靶向药物(基因)载体设计以及抗肿瘤给药系统的构建(缓控释);

3.载药超声造影剂用于可视化治疗;

4.温敏复合凝胶给药系统对肿瘤的治疗;

5.生物标志物检测。


科研论文

1.       Yanhua Zhang, Yang Dong, Hao Fu, Hui Huang, Zhihua Wu, Meng Zhao, Xupeng Yang, Qianqian Guo, Yourong Duan, Ying Sun. Multifunctional tumor-targeted PLGA nanoparticles delivering Pt(IV)/siBIRC5 for US/MRI imaging and overcoming ovarian cancer resistance. Biomaterials. 2021, 120478. (通讯作者)

2.       De Zhao, Zhihua Wu, Jian Yu, Hongzhi Wang, Yaogang Li, Yourong Duan. Highly sensitive microfluidic detection of carcinoembryonic antigen via a synergetic fluorescence enhancement strategy based on the micro/nanostructure optimization of ZnO nanorod arrays and in situ ZIF-8 coating. Chemical Engineering Journal. 2020, 383: 123230. (通讯作者)

3.       Jiali Zhang, Chuanrong Chen, Hao Fu, Jian Yu, Ying Sun, Hui Huang, Yuanjia Tang, Nan Shen, Yourong Duan. MicroRNA-125a-Loaded Polymeric Nanoparticles Alleviate Systemic Lupus Erythematosus by Restoring Effector/Regulatory T Cells Balance. ACS Nano, 2020, 14, 4414-4429. (通讯作者)

4.       Qi Wang, Xiangyu Zhang, Ying Sun, Liting Wang, Li Ding, Wei-Hong Zhu, Wen Di, You-Rong Duan. Gold-caged copolymer nanoparticles as multimodal synergistic photodynamic/photothermal/chemotherapy platform against lethality androgen-resistant prostate cancer. Biomaterials. 2019, 22: 73-86. (通讯作者)

5.       Hui Huang, Yang Dong, Yanhua Zhang, Dan Ru, Zhihua Wu, Jiali Zhang, Ming Shen, Yourong Duan, Ying Sun. GSH-sensitive Pt(IV) prodrug-loaded phase-transitional nanoparticles with a hybrid lipid-polymer shell for precise theranostics against ovarian cancer. Theranostics. 2019, 9(4): 1047-1065. (通讯作者)

6.       Hao Fu, Chongchong Miao, Yuanpeng Rui, Fenglin Hu , Ming Shen , Hong Xu , Chunfu Zhang , Yi Dong, Wenping Wang, Hongchen Gu, Yourong Duan. Strategy to prevent cardiac toxicity induced by polyacrylic acid decorated iron oxide nanoparticles and its mechanism investigation. Biomaterials. 2019, 222: 119442. (通讯作者)

7.       Dong Yang, Liao Hongze, Fu Hao, Yu Jian, Guo Qian, Wang Qi, Duan Yourong. pH-Sensitive Shell-Core Platform Block DNA Repair Pathway To Amplify Irreversible DNA Damage of Triple Negative Breast Cancer. ACS Appl Mater Interfaces. 2019, 42: 38417-38428. (通讯作者)

8.       Qi Wang, Xiangyu Zhang, Hongze Liao, Ying Sun, Li Ding, Yanwei Teng, Wei-Hong Zhu, Zhirong Zhang, Yourong Duan. Multifunctional Shell–Core Nanoparticles for Treatment of Multidrug Resistance Hepatocellular Carcinoma. 2018, 201706124 (通讯作者)

9.       Ying Sun, Qi Wang, Jianhua Chen, Lei Liu, Li Ding, Ming Shen, Jin Li, Baoshan Han, Yourong Duan. Temperature-Sensitive Gold Nanoparticle-Coated Pluronic-PLL Nanoparticles for Drug Delivery and Chemo-Photothermal Therapy. Theranostics, 2017, 7(18): 4424-4444. (通讯作者)

10.   Li Ding, Qi Wang, Ming Shen, Ying Sun, Xiangyu Zhang, Can Huang, Jianhua Chen, Rongxin Li, Yourong Duan. Thermoresponsive Nanocomposite Gel for Local Drug Delivery to Suppress the Growth of Glioma by Inducing Autophagy. Autophagy. 2017, 13(7): 1176-1190. (通讯作者)

11.   Jianhua Chen, Pei Gao, Sujing Yuan, Rongxin Li, Aimin Ni, Liang Chu, Li Ding, Ying Sun, Xinyuan Liu, Yourong Duan. Oncolytic Adenovirus Complexes Coated with Lipids and Calcium Phosphate for Cancer Gene Therapy. ACS Nano. 2016, 10: 11548-11560. (通讯作者)

12.   Can Huang, Ying Sun, Ming Shen, Xiangyu Zhang, Pei Gao, Yourong Duan. Altered Cell Cycle Arrest by Multifunctional Drug Loaded Enzymatically-Triggered Nanoparticles. ACS Applied Materials & Interfaces. 2016, 8: 1360?1370. (通讯作者)

13.   Wang Qi, Sun Ying, Zhang Zhirong, Duan Yourong. Targeted polymeric therapeutic nanoparticles: Design and interactions with hepatocellular carcinoma. Biomaterials. 2015, 56: 229-240. (通讯作者)

14.   Shen Ming, Xu Yuanyuan, Sun Ying, Han Baoshan, Duan Yourong. Preparation of a Thermosensitive Gel Composed of a mPEG-PLGA-PLL-cRGD Nanodrug Delivery System for Pancreatic Tumor Therapy. ACS Applied Materials & Interfaces. 2015, 7: 20530?20537. (通讯作者)

15.   Qi Wang, Peifeng Liu, Ying Sun, Tao gong, Xun Sun, Mingjie Zhu, Zhirong zhang, Yourong Duan. Preparation and properties of biocompatible PS-PEG/calcium phosphate nanospheres. Nanotoxicology, 2015, 9(2): 190-200. (通讯作者)

16.   Zelai He, Ying Sun, Qi Wang, Ming Shen, Mingjie Zhu, Fengqian Li, Yourong Duan. Degradation and Bio-Safety Evaluation of mPEG-PLGA-PLL-Copolymer-Prepared Nanoparticles. Journal of Physical Chemistry C. 2015, 119(6): 3348-3362. (通讯作者)


科研项目

1. 国家自然科学基金面上项目,81972886,PRSS22介导的递送系统实现多靶定向敲除克服非小细胞肺癌耐药与转移的研究

2. 国家自然科学基金面上项目,81773272,共载siRNA/PTX序贯释放“双管齐下”抗前列腺癌耐药研究

3. 国家自然科学基金面上项目,81472841,磷脂/磷酸钙壳核组装序贯给药克服脑胶质瘤细胞耐药研究

4. 国家自然科学基金面上项目,81272568,两相释药降低乳腺癌细胞耐药靶向给药系统的研究

获得专利

1.      磷酸钙和两亲性聚合物复合载药纳米微球、制备方法和用途. 中国,ZL200910198765.X

2.      聚乙二醇-聚乳酸羟基乙酸-聚赖氨酸纳米递送系统、制备方法及其应用. 中国,ZL200910247576.7

3.      用于治疗肿瘤的药物缓释血管栓塞凝胶剂及其制备方法. 中国,ZL201110088056.3

4.      注射用整合素配体修饰的载药肿瘤靶向阳离子聚合物. 中国,ZL200710039337.3

5.      双腔微导管. 中国,ZL201620276998.2

6.      核壳结构聚合物/纳米金复合纳米材料及其制备方法和应用. 中国,ZL201210246282.4

7.      一种预防和治疗前列腺炎穴位缓释贴片及其制品、制备方法和用途. 中国,ZL200710043634.5

8.      脂质体硫酸钙复合纳米人工骨、制备方法和应用. 中国,ZL200910048164.0

9.      仿生磷脂聚合物细胞膜及其制备方法和用途. 中国,ZL200710129554.1

10.  肿瘤细胞及肿瘤血管双靶向纳米粒、构建方法及应用. 中国,ZL 201510503842.3

11.  一种治疗胆系肿瘤的药物纳米复合温敏凝胶剂. 中国,ZL201610046742.7

12.  一种复合显影温敏凝胶栓塞剂、制备方法及其应用. 中国,ZL201610207908.9

实验室成员

工作人员

孙颖     副研究员(硕士生导师)    ysun@shsci.org

张佳利   助理研究员                jlzhang@shsci.org

张伟     助理研究员                wzhang@shsci.org

武志华   助理研究员                zhwu@shsci.org

余坚     副主任技师                yujian@shsci.org

田宇     助理研究员                ytian@shsci.org

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